My name is Dena Goldberg and I’m a genetic counselor at the University of California, San Francisco, who specializes in cancer genetics. I see patients and their relatives with a personal or family history of cancer, tumors, or polyps, and use their history to determine the most appropriate genetic test. I use genetic test results […]
Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative
Testing those diagnosed with a disease is the most efficient way to identify carriers of predisposing germline genetic variants, and is consistent with clinical practice guidelines. To achieve the goal of genetically targeted primary disease prevention, testing for an identified familial pathogenic variant must then extend to disease-free relatives in a process known as “cascade […]
At SF synagogue: BRCA, Cancer and Ashkenazi Genetics
One in 40 Ashkenazi Jews has a gene mutation that drastically increases the chance of certain cancers — and Gail Fisher thinks people need to know about it. Go to article
bioRxiv The PrePrint Server for Biology
Germline mutations in the BRCA1 and BRCA2 genes predispose carriers to breast and ovarian cancer, and there remains a need to identify the specific genomic mechanisms by which cancer evolves in these patients. Here we present a systematic genomic analysis of breast tumors with BRCA1 and BRCA2 mutations, comparing these to common types of sporadic […]
Looking Toward the Future of Cancer Treatment with Dr. Allison Kurian
Over the course of my BRCA Journal posts, I have highlighted emerging technologies and highly tailored therapeutics. These exciting innovations have the potential to change the way cancer is studied and treated. While they advance the trend of personalized medicine, they currently only benefit a small portion of cancer patients. Existing treatments have proven highly […]